Two sample MR report
IRF5_Alveolar Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0763681 | 0.3310748 | 0.8390209 |
| Weighted median | 4 | 0.0371818 | 0.0155060 | 0.0164895 |
| Inverse variance weighted | 4 | 0.0376253 | 0.0132444 | 0.0044993 |
| Simple mode | 4 | 0.0429685 | 0.0200854 | 0.1219352 |
| Weighted mode | 4 | 0.0327846 | 0.0182234 | 0.1698430 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0872279 | 2 | 0.9573234 |
| Inverse variance weighted | 0.2059696 | 3 | 0.9766199 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0525179 | 0.1524074 | 0.763265 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.16e-05 | 0 | TRUE | 0.5951262 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
